Antibodies and Viral Epitopes (Lesson for Middle/High School)

  • Uploaded By: Claire Gordy
  • For Citation:Bergman, M., Goller, C.C., Hasley, A.O., Sjogren, C.A. 2022. Antibodies and Viral Epitopes Lesson.
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Lesson Overview

This lesson uses 3D printed influenza virus and SARS-CoV2 models along with antibody heavy and light chain models printed with flexible filament to engage middle and high school students in learning concepts related to antibody-epitope binding, vaccines, and immune responses. This lesson is adapted from an activity created for in-person instruction of undergraduate students, and is designed for remote implementation using Zoom and an activity website.

Learning Outcomes

Upon completion of this activity, students will be able to:
  1. Describe how antigens and epitopes are related using examples of virus antigens.
  2. Explain why some antibodies that do not bind to epitopes are produced.

These learning outcomes are aligned with the North Carolina Standard Course of Study Science Standards:

Middle Grades 6-8:

  • Bio.4.1 Understand how biological molecules are essential to the survival of living organisms
  • Bio.4.1.1 Compare the structures and functions of the major biological molecules (carbohydrates, proteins, lipids, and nucleic acids) as related to the survival of living organisms.

High School Biology: